Dr. Brian Jameson, a former Ph.D. student in chemistry, and Dr. Rainer Glaser, professor of chemistry, published an article titled “VT-NMR Analysis of Rotation-Inversion of N-(4-hydroxybutyl)-N-(2,2,2-trifluoroethyl) tert-butyl Carbamate: Utilizing the −CH2CF3 Appendage as a Reporter on E/Z-Isomerization,” in the ChemistrySelect, a journal for original authoritative cross-disciplinary research.
In this paper, the authors describe results of physical-organic studies by variable-temperature (VT) nuclear magnetic resonance (NMR) spectroscopy. The results present a contribution to the field of intramolecular dynamics and the electronic structures of carbamates and, more generally, the new methods for advanced line shape analysis present a major conceptual advance to the evaluation of VT-NMR studies.
The image shows J(13C,19F) coupled 13C NMR spectra as a function of temperature and the insert sets the stage for the innovative Lorentzian line shape analysis informed by data covering the entire temperature range.