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Adam Martin, cDNA lab manager, will present a seminar titled “Constitutive Activity in Orphan G Protein Coupled Receptors” at 3 p.m. Monday, May 4, in Room 126 Schrenk Hall.
The goal of Martin’s research was to use a distal signaling pathway analysis to evaluate the extent of agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). His results suggest that identification of inverse agonists may be a fruitful approach for categorizing these orphan receptors and targeting them for pharmacological intervention.